4CV3

Crystal structure of E. coli FabI in complex with NADH and PT166

4CV3 の概要

• エントリーDOI: 10.2210/pdb4cv3/pdb
• 関連するPDBエントリー: 4CUZ 4CV0 4CV1 4CV2
• 分子名称: ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], 2-hexyl-1-methyl-5-(2-methylphenoxy)pyridin-4(1H)-one, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... (4 entities in total)
• 機能のキーワード: short-chain dehydrogenase/reductase superfamily, fatty acid biosynthesis, lipid synthesis, ecfabi, oxidoreductase
• 由来する生物種: ESCHERICHIA COLI
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59857.83

構造登録者

Eltschkner, S.,Schiebel, J.,Chang, A.,Shah, S.,Tonge, P.J.,Kisker, C. (登録日: 2014-03-22, 公開日: 2014-04-16, 最終更新日: 2023-12-20)

• 主引用文献: Schiebel, J.,Chang, A.,Shah, S.,Lu, Y.,Liu, L.,Pan, P.,Hirschbeck, M.W.,Tareilus, M.,Eltschkner, S.,Yu, W.,Cummings, J.E.,Knudson, S.E.,Bommineni, G.R.,Walker, S.G.,Slayden, R.A.,Sotriffer, C.A.,Tonge, P.J.,Kisker, C.; Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (Acp) Reductase Inhibitor.; J.Biol.Chem., 289:15987-, 2014; PubMed: 24739388; DOI: 10.1074/JBC.M113.532804

実験手法

X-RAY DIFFRACTION (1.95 Å)