4CV0

Crystal structure of S. aureus FabI in complex with NADPH and CG400549 (small unit cell)

4CV0 の概要

• エントリーDOI: 10.2210/pdb4cv0/pdb
• 関連するPDBエントリー: 4CUZ 4CV1 4CV2 4CV3
• 分子名称: ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1-(3-amino-2-methylbenzyl)-4-[2-(thiophen-2-yl)ethoxy]pyridin-2(1H)-one, ... (6 entities in total)
• 機能のキーワード: short-chain dehydrogenase/reductase superfamily, fatty acid biosynthesis, lipid synthesis, safabi, oxidoreductase
• 由来する生物種: STAPHYLOCOCCUS AUREUS
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 129332.72

構造登録者

Schiebel, J.,Chang, A.,Shah, S.,Tonge, P.J.,Kisker, C. (登録日: 2014-03-22, 公開日: 2014-04-16, 最終更新日: 2023-12-20)

• 主引用文献: Schiebel, J.,Chang, A.,Shah, S.,Lu, Y.,Liu, L.,Pan, P.,Hirschbeck, M.W.,Tareilus, M.,Eltschkner, S.,Yu, W.,Cummings, J.E.,Knudson, S.E.,Bommineni, G.R.,Walker, S.G.,Slayden, R.A.,Sotriffer, C.A.,Tonge, P.J.,Kisker, C.; Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (Acp) Reductase Inhibitor.; J.Biol.Chem., 289:15987-, 2014; PubMed: 24739388; DOI: 10.1074/JBC.M113.532804

実験手法

X-RAY DIFFRACTION (2.2 Å)