4CUZ
Crystal structure of S. aureus FabI in complex with NADPH and PT173
Summary for 4CUZ
Entry DOI | 10.2210/pdb4cuz/pdb |
Related | 4CV0 4CV1 4CV2 4CV3 |
Descriptor | ENOYL-ACP REDUCTASE MOLECULE ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], 1-(3-amino-2-methylbenzyl)-4-hexylpyridin-2(1H)-one, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | short-chain dehydrogenase/reductase superfamily, fatty acid biosynthesis, lipid synthesis, safabi, oxidoreductase |
Biological source | STAPHYLOCOCCUS AUREUS |
Total number of polymer chains | 8 |
Total formula weight | 257302.31 |
Authors | Schiebel, J.,Chang, A.,Shah, S.,Tonge, P.J.,Kisker, C. (deposition date: 2014-03-22, release date: 2014-04-16, Last modification date: 2024-05-01) |
Primary citation | Schiebel, J.,Chang, A.,Shah, S.,Lu, Y.,Liu, L.,Pan, P.,Hirschbeck, M.W.,Tareilus, M.,Eltschkner, S.,Yu, W.,Cummings, J.E.,Knudson, S.E.,Bommineni, G.R.,Walker, S.G.,Slayden, R.A.,Sotriffer, C.A.,Tonge, P.J.,Kisker, C. Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (Acp) Reductase Inhibitor. J.Biol.Chem., 289:15987-, 2014 Cited by PubMed: 24739388DOI: 10.1074/JBC.M113.532804 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
Download full validation report