4CUF

Human Notch1 EGF domains 11-13 mutant T466S

4CUF の概要

• エントリーDOI: 10.2210/pdb4cuf/pdb
• 関連するPDBエントリー: 4CUD 4CUE
• 分子名称: NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1, CALCIUM ION, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: transcription, metal-binding, transmembrane, developmental, protein, notch signaling pathway, differentiation, phosphorylation, egf-like domain, regulation, receptor, activator, ank repeat, signalling, glycoprotein, extracellular, egf, jagged, nucleus, membrane
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein . Notch 1 intracellular domain: Nucleus : P46531
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15025.88

構造登録者

Taylor, P.,Takeuchi, H.,Sheppard, D.,Chillakuri, C.,Lea, S.M.,Haltiwanger, R.S.,Handford, P.A. (登録日: 2014-03-18, 公開日: 2014-05-14, 最終更新日: 2023-12-20)

• 主引用文献: Taylor, P.,Takeuchi, H.,Sheppard, D.,Chillakuri, C.,Lea, S.M.,Haltiwanger, R.S.,Handford, P.A.; Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.; Proc.Natl.Acad.Sci.USA, 111:7290-, 2014; PubMed: 24803430; DOI: 10.1073/PNAS.1319683111

実験手法

X-RAY DIFFRACTION (2.29 Å)