4CTX

Structure of rat neuronal nitric oxide synthase heme domain in complex with (S)-6-(3-amino-2-(5-(2-(6-amino-4-methylpyridin-2-yl) ethyl)pyridin-3-yl)propyl)-4-methylpyridin-2-amine

Summary for 4CTX

Entry DOI	10.2210/pdb4ctx/pdb
Related	4CTP 4CTQ 4CTR 4CTT 4CTU 4CTV 4CTW 4CTY 4CTZ 4CU0 4CU1
Descriptor	NITRIC OXIDE SYNTHASE, BRAIN, ZINC ION, PROTOPORPHYRIN IX CONTAINING FE, ... (7 entities in total)
Functional Keywords	oxidoreductase, inhibitor complex
Biological source	RATTUS NORVEGICUS (NORWAY RAT)
Cellular location	Cell membrane, sarcolemma; Peripheral membrane protein (By similarity): P29476
Total number of polymer chains	2
Total formula weight	100277.02
Authors	Li, H.,Poulos, T.L. (deposition date: 2014-03-15, release date: 2014-05-07, Last modification date: 2014-06-04)
Primary citation	Kang, S.,Tang, W.,Li, H.,Chreifi, G.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Nitric Oxide Synthase Inhibitors that Interact with Both a Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity. J.Med.Chem., 57:4382-, 2014 Cited by PubMed: 24758147 DOI: 10.1021/JM5004182 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.82 Å)

Structure validation