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4CTV

Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(3-amino-2-(6-(2-(6-amino-4-methylpyridin-2-yl)ethyl) pyridin-2-yl)propyl)-4-methylpyridin-2-amine

Summary for 4CTV
Entry DOI10.2210/pdb4ctv/pdb
Related4CTP 4CTQ 4CTR 4CTT 4CTU 4CTW 4CTX 4CTY 4CTZ 4CU0 4CU1
DescriptorNITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywordsoxidoreductase, inhibitor complex
Biological sourceRATTUS NORVEGICUS (NORWAY RAT)
Cellular locationCell membrane, sarcolemma; Peripheral membrane protein (By similarity): P29476
Total number of polymer chains2
Total formula weight100277.02
Authors
Li, H.,Poulos, T.L. (deposition date: 2014-03-15, release date: 2014-05-07, Last modification date: 2014-06-04)
Primary citationKang, S.,Tang, W.,Li, H.,Chreifi, G.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.
Nitric Oxide Synthase Inhibitors that Interact with Both a Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity.
J.Med.Chem., 57:4382-, 2014
Cited by
PubMed: 24758147
DOI: 10.1021/JM5004182
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.78 Å)
Structure validation

217705

数据于2024-03-27公开中

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