4CTM

Glucopyranosylidene-spiro-iminothiazolidinone, a New Bicyclic Ring System: Synthesis, Derivatization, and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetic and Crystallographic Methods

4CTM の概要

• エントリーDOI: 10.2210/pdb4ctm/pdb
• 関連するPDBエントリー: 4CTN 4CTO
• 分子名称: GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, (5R,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-2-imino-6-oxa-1-thia-3-azaspiro[4.5]decan-4-one, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: transferase, type 2 diabetes, inhibitor, structure-based drug design
• 由来する生物種: ORYCTOLAGUS CUNICULUS (RABBIT)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 98028.77

構造登録者

Alexacou, K.M.,Papakonstantinou, M.,Leonidas, D.D.,Zographos, S.E.,Chrysina, E.D. (登録日: 2014-03-15, 公開日: 2014-08-06, 最終更新日: 2023-12-20)

• 主引用文献: Czifrak, K.,Deak, S.,Pahi, A.,Kover, K.E.,Docsa, T.,Gergely, P.,Alexacou, K.M.,Papakonstantinou, M.,Leonidas, D.D.,Zographos, S.E.,Chrysina, E.D.,Somsak, L.; Glucopyranosylidene-Spiro-Iminothiazolidinone, a New Bicyclic Ring System: Synthesis, Derivatization, and Evaluation for Inhibition of Glycogen Phosphorylase by Enzyme Kinetic and Crystallographic Methods.; Bioorg.Med.Chem., 22:4028-, 2014; PubMed: 25009003; DOI: 10.1016/J.BMC.2014.05.076

実験手法

X-RAY DIFFRACTION (1.95 Å)