4CTK

DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 2A4

Summary for 4CTK

Entry DOI	10.2210/pdb4ctk/pdb
Related	4CTJ
Descriptor	POLYPROTEIN, S-ADENOSYLMETHIONINE, thieno[2,3-b]pyrazin-7-amine, ... (6 entities in total)
Functional Keywords	transferase, dengue virus, ns5 methyltransferase, fragment-based drug discovery, antiviral screening
Biological source	DENGUE VIRUS 3
Cellular location	Virion membrane ; Multi-pass membrane protein : A9LIE0
Total number of polymer chains	2
Total formula weight	63614.00
Authors	Barral, K.,Bricogne, G.,Sharff, A. (deposition date: 2014-03-14, release date: 2014-04-16, Last modification date: 2024-05-08)
Primary citation	Coutard, B.,Decroly, E.,Li, C.,Sharff, A.,Lescar, J.,Bricogne, G.,Barral, K. Assessment of Dengue Virus Helicase and Methyltransferase as Targets for Fragment-Based Drug Discovery. Antiviral Res., 106:61-, 2014 Cited by PubMed: 24704437 DOI: 10.1016/J.ANTIVIRAL.2014.03.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation