4CTJ
DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 3A9
Summary for 4CTJ
Entry DOI | 10.2210/pdb4ctj/pdb |
Related | 4CTK |
Descriptor | NON-STRUCTURAL PROTEIN 5, S-ADENOSYLMETHIONINE, 2,3-dihydro-1-benzofuran-5-carboxylic acid, ... (5 entities in total) |
Functional Keywords | transferase, ns5 methyltransferase, fragment-based drug discovery, antiviral screening |
Biological source | DENGUE VIRUS 3 |
Cellular location | Virion membrane; Multi-pass membrane protein: A9LIE0 |
Total number of polymer chains | 2 |
Total formula weight | 63397.65 |
Authors | Barral, K.,Bricogne, G.,Sharff, A. (deposition date: 2014-03-14, release date: 2014-04-16, Last modification date: 2024-05-08) |
Primary citation | Coutard, B.,Decroly, E.,Li, C.,Sharff, A.,Lescar, J.,Bricogne, G.,Barral, K. Assessment of Dengue Virus Helicase and Methyltransferase as Targets for Fragment-Based Drug Discovery. Antiviral Res., 106:61-, 2014 Cited by PubMed: 24704437DOI: 10.1016/J.ANTIVIRAL.2014.03.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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