4CTH

Neprilysin variant G399V,G714K in complex with phosphoramidon

Summary for 4CTH

Entry DOI	10.2210/pdb4cth/pdb
Related PRD ID	PRD_000638
Descriptor	NEPRILYSIN, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (6 entities in total)
Functional Keywords	transferase, amyloid beta, alzheimer's disease, enzyme engineering
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	83423.82
Authors	Webster, C.I.,Burrell, M.,Olsson, L.,Fowler, S.B.,Digby, S.,Sandercock, A.,Snijder, A.,Tebbe, J.,Haupts, U.,Grudzinska, J.,Jermutus, L.,Andersson, C. (deposition date: 2014-03-13, release date: 2014-08-13, Last modification date: 2023-12-20)
Primary citation	Webster, C.I.,Burrell, M.,Olsson, L.,Fowler, S.B.,Digby, S.,Sandercock, A.,Snijder, A.,Tebbe, J.,Haupts, U.,Grudzinska, J.,Jermutus, L.,Andersson, C. Engineering Neprilysin Activity and Specificity to Create a Novel Therapeutic for Alzheimer'S Disease. Plos One, 9:04001-, 2014 Cited by PubMed: 25089527 DOI: 10.1371/JOURNAL.PONE.0104001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation