4CTH

Neprilysin variant G399V,G714K in complex with phosphoramidon

4CTH の概要

• エントリーDOI: 10.2210/pdb4cth/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000638
• 分子名称: NEPRILYSIN, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (6 entities in total)
• 機能のキーワード: transferase, amyloid beta, alzheimer's disease, enzyme engineering
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 83423.82

構造登録者

Webster, C.I.,Burrell, M.,Olsson, L.,Fowler, S.B.,Digby, S.,Sandercock, A.,Snijder, A.,Tebbe, J.,Haupts, U.,Grudzinska, J.,Jermutus, L.,Andersson, C. (登録日: 2014-03-13, 公開日: 2014-08-13, 最終更新日: 2023-12-20)

• 主引用文献: Webster, C.I.,Burrell, M.,Olsson, L.,Fowler, S.B.,Digby, S.,Sandercock, A.,Snijder, A.,Tebbe, J.,Haupts, U.,Grudzinska, J.,Jermutus, L.,Andersson, C.; Engineering Neprilysin Activity and Specificity to Create a Novel Therapeutic for Alzheimer'S Disease.; Plos One, 9:04001-, 2014; PubMed: 25089527; DOI: 10.1371/JOURNAL.PONE.0104001

実験手法

X-RAY DIFFRACTION (2.15 Å)