4CSV

Tyrosine kinase AS - a common ancestor of Src and Abl bound to Gleevec

4CSV の概要

• エントリーDOI: 10.2210/pdb4csv/pdb
• 分子名称: SRC-ABL TYROSINE KINASE ANCESTOR, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE (3 entities in total)
• 機能のキーワード: transferase, dfg
• 由来する生物種: SYNTHETIC CONSTRUCT
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31750.13

構造登録者

Kutter, S.,Wilson, C.,Cruz, L.,Agafonov, R.V.,Hoemberger, M.S.,Zorba, A.,Kern, D. (登録日: 2014-03-10, 公開日: 2015-03-04, 最終更新日: 2023-12-20)

• 主引用文献: Wilson, C.,Agafonov, R.V.,Hoemberger, M.,Kutter, S.,Zorba, A.,Halpin, J.,Buosi, V.,Otten, R.,Waterman, D.,Theobald, D.L.,Kern, D.; Kinase Dynamics. Using Ancient Protein Kinases to Unravel a Modern Cancer Drug'S Mechanism.; Science, 347:882-, 2015; PubMed: 25700521; DOI: 10.1126/SCIENCE.AAA1823

実験手法

X-RAY DIFFRACTION (2.05 Å)