4CST
Crystal structure of FimH in complex with 3'-Chloro-4'-(alpha-D-mannopyranosyloxy)-biphenyl-4-carbonitrile
Summary for 4CST
Entry DOI | 10.2210/pdb4cst/pdb |
Related | 4CSS 4CSY |
Descriptor | PROTEIN FIMH, 3'-chloro-4'-(alpha-D-mannopyranosyloxy)biphenyl-4-carbonitrile (3 entities in total) |
Functional Keywords | sugar binding protein, fimh antagonists, type i pili, uti, upec, adhesin |
Biological source | ESCHERICHIA COLI K-12 |
Total number of polymer chains | 1 |
Total formula weight | 17832.28 |
Authors | Kleeb, S.,Pang, L.,Mayer, K.,Sigl, A.,Eris, D.,Preston, R.C.,Zihlmann, P.,Abgottspon, D.,Hutter, A.,Scharenberg, M.,Jian, X.,Navarra, G.,Rabbani, S.,Smiesko, M.,Luedin, N.,Jakob, R.P.,Schwardt, O.,Maier, T.,Sharpe, T.,Ernst, B. (deposition date: 2014-03-10, release date: 2015-02-25, Last modification date: 2023-12-20) |
Primary citation | Ernst, B.,Kleeb, S.,Pang, L.,Mayer, K.,Eris, D.,Sigl, A.,Zihlmann, P.,Preston, R.C.,Sharpe, T.,Jakob, R.,Abgottspon, D.,Hutter, A.S.,Scharenberg, M.,Jiang, X.,Navarra, G.,Rabbani, S.,Smiesko, M.,Ludin, N.,Bezencon, J.,Schwardt, O.,Maier, T. Fimh Antagonists: Bioisosteres to Improve the in Vitro and in Vivo Pk/Pd Profile. J.Med.Chem., 58:2221-, 2015 Cited by PubMed: 25666045DOI: 10.1021/JM501524Q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.1 Å) |
Structure validation
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