4CRT
Crystal structure of human monoamine oxidase B in complex with the multi-target inhibitor ASS234
4CRT の概要
エントリーDOI | 10.2210/pdb4crt/pdb |
分子名称 | AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, (E)-N-methyl-N-[[1-methyl-5-[3-[1-(phenylmethyl)piperidin-4-yl]propoxy]indol-2-yl]methyl]prop-1-en-1-amine, ... (4 entities in total) |
機能のキーワード | oxidoreductase, enzyme, flavin, drug design, alzheimer's disease |
由来する生物種 | HOMO SAPIENS (HUMAN) |
細胞内の位置 | Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 120137.84 |
構造登録者 | Esteban, G.,Allan, J.,Samadi, A.,Mattevi, A.,Unzeta, M.,Marco-Contelles, J.,Binda, C.,Ramsay, R.R. (登録日: 2014-02-28, 公開日: 2014-04-02, 最終更新日: 2014-05-07) |
主引用文献 | Esteban, G.,Allan, J.,Samadi, A.,Mattevi, A.,Unzeta, M.,Marco-Contelles, J.,Binda, C.,Ramsay, R.R. Kinetic and Structural Analysis of the Irreversible Inhibition of Human Monoamine Oxidases by Ass234, a Multi-Target Compound Designed for Use in Alzheimer'S Disease. Biochim.Biophys.Acta, 1844:1104-, 2014 Cited by PubMed: 24642166DOI: 10.1016/J.BBAPAP.2014.03.006 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.8 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード