4CRT

Crystal structure of human monoamine oxidase B in complex with the multi-target inhibitor ASS234

4CRT の概要

• エントリーDOI: 10.2210/pdb4crt/pdb
• 分子名称: AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, (E)-N-methyl-N-[[1-methyl-5-[3-[1-(phenylmethyl)piperidin-4-yl]propoxy]indol-2-yl]methyl]prop-1-en-1-amine, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, enzyme, flavin, drug design, alzheimer's disease
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 120137.84

構造登録者

Esteban, G.,Allan, J.,Samadi, A.,Mattevi, A.,Unzeta, M.,Marco-Contelles, J.,Binda, C.,Ramsay, R.R. (登録日: 2014-02-28, 公開日: 2014-04-02, 最終更新日: 2014-05-07)

• 主引用文献: Esteban, G.,Allan, J.,Samadi, A.,Mattevi, A.,Unzeta, M.,Marco-Contelles, J.,Binda, C.,Ramsay, R.R.; Kinetic and Structural Analysis of the Irreversible Inhibition of Human Monoamine Oxidases by Ass234, a Multi-Target Compound Designed for Use in Alzheimer'S Disease.; Biochim.Biophys.Acta, 1844:1104-, 2014; PubMed: 24642166; DOI: 10.1016/J.BBAPAP.2014.03.006

実験手法

X-RAY DIFFRACTION (1.8 Å)