4CRJ
Staphylococcus aureus 7,8-Dihydro-6-hydroxymethylpterin- pyrophosphokinase in complex with AMPCPP and an inhibitor
4CRJ の概要
エントリーDOI | 10.2210/pdb4crj/pdb |
分子名称 | 7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE (HPPK), DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, MAGNESIUM ION, ... (6 entities in total) |
機能のキーワード | transferase, folate, structure-based drug design |
由来する生物種 | STAPHYLOCOCCUS AUREUS |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 19251.27 |
構造登録者 | |
主引用文献 | Dennis, M.L.,Chhabra, S.,Wang, Z.,Debono, A.,Dolezal, O.,Newman, J.,Pitcher, N.P.,Rahmani, R.,Cleary, B.,Barlow, N.,Hattarki, M.,Graham, B.,Peat, T.S.,Baell, J.B.,Swarbrick, J.D. Structure-Based Design and Development of Functionalized Mercaptoguanine Derivatives as Inhibitors of the Folate Biosynthesis Pathway Enzyme 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase from Staphylococcus Aureus. J.Med.Chem., 57:9612-, 2014 Cited by PubMed: 25357262DOI: 10.1021/JM501417F 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
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