4CR5

Creating novel F1 inhibitors through fragment based lead generation and structure aided drug design

4CR5 の概要

• エントリーDOI: 10.2210/pdb4cr5/pdb
• 分子名称: COAGULATION FACTOR XIA, 6-chloroquinolin-2(1H)-one, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: hydrolase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Secreted: P03951
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27604.41

構造登録者

Sandmark, J.,Oster, L.,Fjellstrom, O.,Akkaya, S.,Beisel, H.G.,Eriksson, P.O.,Erixon, K.,Gustafsson, D.,Jurva, U.,Kang, D.,Karis, D.,Knecht, W.,Nerme, V.,Nilsson, I.,Olsson, T.,Redzic, A.,Roth, R.,Tigerstrom, A. (登録日: 2014-02-25, 公開日: 2015-02-11, 最終更新日: 2018-04-04)

• 主引用文献: Fjellstrom, O.,Akkaya, S.,Beisel, H.,Eriksson, P.,Erixon, K.,Gustafsson, D.,Jurva, U.,Kang, D.,Karis, D.,Knecht, W.,Nerme, V.,Nilsson, I.,Olsson, T.,Redzic, A.,Roth, R.,Sandmark, J.,Tigerstrom, A.,Oster, L.; Creating Novel Activated Factor Xi Inhibitors Through Fragment Based Lead Generation and Structure Aided Drug Design.; Plos One, 10:13705-, 2015; PubMed: 25629509; DOI: 10.1371/JOURNAL.PONE.0113705

実験手法

X-RAY DIFFRACTION (2 Å)