4CPL

Structure of the Neuraminidase from the B/Brisbane/60/2008 virus.

4CPL の概要

• エントリーDOI: 10.2210/pdb4cpl/pdb
• 関連するPDBエントリー: 4CPM 4CPN 4CPO 4CPY 4CPZ
• 分子名称: NEURAMINIDASE, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: hydrolase
• 由来する生物種: INFLUENZA B VIRUS (B/BRISBANE/60/2008)
• 細胞内の位置: Virion membrane : C0LT34
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 104101.22

構造登録者

Vachieri, S.G.,Collins, P.J.,Escuret, V.,Casalegno, J.S.,Cattle, N.,Ferraris, O.,Sabatier, M.,Frobert, E.,Caro, V.,Skehel, J.J.,Gamblin, S.J.,Valla, F.,Valette, M.,Ottmann, M.,McCauley, J.W.,Daniels, R.S.,Lina, B. (登録日: 2014-02-07, 公開日: 2014-05-14, 最終更新日: 2024-10-16)

主引用文献

Escuret, V.,Collins, P.J.,Casalegno, J.,Vachieri, S.G.,Cattle, N.,Ferraris, O.,Sabatier, M.,Frobert, E.,Caro, V.,Skehel, J.J.,Gamblin, S.,Valla, F.,Valette, M.,Ottmann, M.,Mccauley, J.W.,Daniels, R.S.,Lina, B.
A Novel I221 L Substitution in Neuraminidase Confers High Level Resistance to Oseltamivir in Influenza B Viruses.
J.Infect.Dis., 210:1260-, 2014

PubMed Abstract: Influenza B viruses with a novel I221L substitution in neuraminidase (NA) conferring high-level resistance to oseltamivir were isolated from an immunocompromised patient after prolonged oseltamivir treatment.

PubMed: 24795482
DOI: 10.1093/INFDIS/JIU244

実験手法

X-RAY DIFFRACTION (2 Å)