4CP3

The structure of BCL6 BTB (POZ) domain in complex with the ansamycin antibiotic rifabutin.

Summary for 4CP3

Entry DOI	10.2210/pdb4cp3/pdb
Descriptor	B-CELL LYMPHOMA 6 PROTEIN, RIFABUTIN (3 entities in total)
Functional Keywords	immune system, btb/poz, transcriptional repressor, rifamycin, antibiotic, smrt, inhibitor
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus: P41182
Total number of polymer chains	2
Total formula weight	29304.09
Authors	Evans, S.E.,Fairall, L.,Goult, B.T.,Jamieson, A.G.,Ferrigno, P.K.,Ford, R.,Wagner, S.D.,Schwabe, J.W.R. (deposition date: 2014-01-31, release date: 2014-03-19, Last modification date: 2023-12-20)
Primary citation	Evans, S.E.,Goult, B.T.,Fairall, L.,Jamieson, A.G.,Ko Ferrigno, P.,Ford, R.,Schwabe, J.W.R.,Wagner, S.D. The Ansamycin Antibiotic, Rifamycin Sv, Inhibits Bcl6 Transcriptional Repression and Forms a Complex with the Bcl6-Btb/Poz Domain. Plos One, 9:90889-, 2014 Cited by PubMed: 24595451 DOI: 10.1371/JOURNAL.PONE.0090889 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation