4CP3

The structure of BCL6 BTB (POZ) domain in complex with the ansamycin antibiotic rifabutin.

Summary for 4CP3

DescriptorB-CELL LYMPHOMA 6 PROTEIN, RIFABUTIN (3 entities in total)
Functional Keywordsimmune system, btb/poz, transcriptional repressor, rifamycin, antibiotic, smrt, inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus P41182
Total number of polymer chains2
Total molecular weight29304.09
Authors
Primary citation
Evans, S.E.,Goult, B.T.,Fairall, L.,Jamieson, A.G.,Ko Ferrigno, P.,Ford, R.,Schwabe, J.W.R.,Wagner, S.D.
The Ansamycin Antibiotic, Rifamycin Sv, Inhibits Bcl6 Transcriptional Repression and Forms a Complex with the Bcl6-Btb/Poz Domain.
Plos One, 9:90889-, 2014
PubMed: 24595451 (PDB entries with the same primary citation)
DOI: 10.1371/JOURNAL.PONE.0090889
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27070.4%5.4%1.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4cp3
no rotation
Molmil generated image of 4cp3
rotated about x axis by 90°
Molmil generated image of 4cp3
rotated about y axis by 90°