4COX

CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A NON-SELECTIVE INHIBITOR, INDOMETHACIN

Summary for 4COX

Entry DOI	10.2210/pdb4cox/pdb
Descriptor	CYCLOOXYGENASE-2, 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total)
Functional Keywords	peroxidase, dioxygenase, cyclooxygenase, nonsteroidal antiinflammatory drugs, inflammation, arthritis, prostaglandin, prostaglandin synthase, oxidoreductase
Biological source	Mus musculus (house mouse)
Total number of polymer chains	4
Total formula weight	275826.47
Authors	Kurumbail, R.,Stallings, W. (deposition date: 1996-12-18, release date: 1997-12-24, Last modification date: 2023-08-09)
Primary citation	Kurumbail, R.G.,Stevens, A.M.,Gierse, J.K.,McDonald, J.J.,Stegeman, R.A.,Pak, J.Y.,Gildehaus, D.,Miyashiro, J.M.,Penning, T.D.,Seibert, K.,Isakson, P.C.,Stallings, W.C. Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature, 384:644-648, 1996 Cited by PubMed: 8967954 DOI: 10.1038/384644a0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation