4COO

Crystal structure of human cystathionine beta-synthase (delta516-525) at 2.0 angstrom resolution

4COO の概要

• エントリーDOI: 10.2210/pdb4coo/pdb
• 分子名称: CYSTATHIONINE BETA-SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE, ACETATE ION, ... (8 entities in total)
• 機能のキーワード: lyase, methionine cycle, metabolic pathway, allosteric regulation, serine metabolism
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm : P35520
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 127123.27

構造登録者

McCorvie, T.J.,Kopec, J.,Vollamar, M.,Strain-Damerell, C.,Bushell, S.,Bradley, A.,Tallant, C.,Kiyani, W.,Froese, D.S.,Carpenter, E.S.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.,Edwards, A.,Bountra, C.,Yue, W.W. (登録日: 2014-01-29, 公開日: 2014-03-05, 最終更新日: 2023-12-20)

• 主引用文献: Mccorvie, T.J.,Kopec, J.,Hyung, S.,Fitzpatrick, F.,Feng, X.,Termine, D.,Strain-Damerell, C.,Vollmar, M.,Fleming, J.,Janz, J.M.,Bulawa, C.,Yue, W.W.; Inter-Domain Communication of Human Cystathionine Beta Synthase: Structural Basis of S-Adenosyl-L-Methionine Activation.; J.Biol.Chem., 289:36018-, 2014; PubMed: 25336647; DOI: 10.1074/JBC.M114.610782

実験手法

X-RAY DIFFRACTION (2 Å)