4COH

Crystal structure of Trypanosoma cruzi CYP51 bound to the sulfonamide derivative of the 4-aminopyridyl-based inhibitor

4COH の概要

• エントリーDOI: 10.2210/pdb4coh/pdb
• 分子名称: STEROL 14-ALPHA DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, 2-fluoranyl-N-[(2R)-3-(1H-indol-3-yl)-1-oxidanylidene-1-(pyridin-4-ylamino)propan-2-yl]-4-(4-thiophen-2-ylsulfonylpiperazin-1-yl)benzamide, ... (4 entities in total)
• 機能のキーワード: transferase, cyp51, sterol 14-demethylase, sterol biosynthesis, chagas disease
• 由来する生物種: TRYPANOSOMA CRUZI
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 109698.68

構造登録者

Vieira, D.F.,Choi, J.Y.,Roush, W.R.,Podust, L.M. (登録日: 2014-01-28, 公開日: 2014-04-02, 最終更新日: 2023-12-20)

• 主引用文献: Vieira, D.F.,Choi, J.Y.,Roush, W.R.,Podust, L.M.; Expanding the Binding Envelope of Cyp51 Inhibitors Targeting Trypanosoma Cruzi with 4-Aminopyridyl-Based Sulfonamide Derivatives; Chembiochem, 15:1111-, 2014; PubMed: 24771705; DOI: 10.1002/CBIC.201402027

実験手法

X-RAY DIFFRACTION (2.08 Å)