4CLA
ALTERNATIVE BINDING MODES FOR CHLORAMPHENICOL AND 1-SUBSTITUTED CHLORAMPHENICOL ANALOGUES REVEALED BY SITE-DIRECTED MUTAGENESIS AND X-RAY CRYSTALLOGRAPHY OF CHLORAMPHENICOL ACETYLTRANSFERASE
Summary for 4CLA
Entry DOI | 10.2210/pdb4cla/pdb |
Descriptor | TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE, COBALT (II) ION, CHLORAMPHENICOL, ... (4 entities in total) |
Functional Keywords | transferase (acyltransferase) |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 25496.51 |
Authors | Leslie, A.G.W. (deposition date: 1990-10-23, release date: 1992-01-15, Last modification date: 2024-02-28) |
Primary citation | Murray, I.A.,Lewendon, A.,Williams, J.A.,Cullis, P.M.,Shaw, W.V. Alternative binding modes for chloramphenicol and 1-substituted chloramphenicol analogues revealed by site-directed mutagenesis and X-ray crystallography of chloramphenicol acetyltransferase. Biochemistry, 30:3763-3770, 1991 Cited by PubMed: 2015231DOI: 10.1021/bi00229a025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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