4CL6

Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) from Pseudomonas aeruginosa in complex with N-(4- Chlorobenzyl)-3-(2-furyl)-1H-1,2,4-triazol-5-amine

Summary for 4CL6

Entry DOI	10.2210/pdb4cl6/pdb
Descriptor	3-HYDROXYDECANOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE, N-(4-chlorobenzyl)-5-(furan-2-yl)-1H-1,2,4-triazol-3-amine (3 entities in total)
Functional Keywords	lyase, fatty acid biosynthesis, bacterial virulence, drug discovery
Biological source	PSEUDOMONAS AERUGINOSA PAO1
Total number of polymer chains	5
Total formula weight	95216.19
Authors	Moynie, L.,McMahon, S.A.,Duthie, F.G.,Naismith, J.H. (deposition date: 2014-01-13, release date: 2015-01-21, Last modification date: 2023-12-20)
Primary citation	Moynie, L.,Hope, A.G.,Finzel, K.,Schmidberger, J.,Leckie, S.M.,Schneider, G.,Burkart, M.D.,Smith, A.D.,Gray, D.W.,Naismith, J.H. A Substrate Mimic Allows High Throughput Assay of the Faba Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas Aeruginosa Faba. J.Mol.Biol., 428:108-120, 2016 Cited by PubMed: 26562505 DOI: 10.1016/J.JMB.2015.10.027 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.41 Å)

Structure validation