4CKL

Structure of 55 kDa N-terminal domain of E. coli DNA gyrase A subunit with simocyclinone D8 bound

Summary for 4CKL

• Entry DOI: 10.2210/pdb4ckl/pdb
• Related: 4CKK
• Descriptor: DNA GYRASE SUBUNIT A, SIMOCYCLINONE D8 (3 entities in total)
• Functional Keywords: isomerase, topoisomerase, antibiotic target
• Biological source: ESCHERICHIA COLI
• Cellular location: Cytoplasm (Potential): P0AES5
• Total number of polymer chains: 2
• Total formula weight: 111695.07

Authors

Hearnshaw, S.J.,Edwards, M.J.,Stevenson, C.E.M.,Lawson, D.M.,Maxwell, A. (deposition date: 2014-01-07, release date: 2014-03-12, Last modification date: 2023-12-20)

• Primary citation: Hearnshaw, S.J.,Edwards, M.J.,Stevenson, C.E.,Lawson, D.M.,Maxwell, A.; A New Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8 Bound to DNA Gyrase Gives Fresh Insight Into the Mechanism of Inhibition.; J.Mol.Biol., 426:2023-, 2014; PubMed: 24594357; DOI: 10.1016/J.JMB.2014.02.017

Experimental method

X-RAY DIFFRACTION (2.05 Å)