4CKA
STEROL 14-ALPHA DEMETHYLASE (CYP51)FROM TRYPANOSOMA CRUZI IN COMPLEX WITH (S)-1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)ethyl 4- isopropylphenylcarbamate (LFS)
Summary for 4CKA
Entry DOI | 10.2210/pdb4cka/pdb |
Related | 4CK8 4CK9 |
Descriptor | STEROL 14-ALPHA DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, (1S)-1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)ethyl 4-isopropylphenylcarbamate, ... (4 entities in total) |
Functional Keywords | heme, oxidoreductase, monooxygenase, sterol biosynthesis, eukaryotic membranes, cytochrome p450 fold, endoplasmic reticulum membrane |
Biological source | TRYPANOSOMA CRUZI |
Cellular location | Membrane; Single-pass membrane protein (Potential): Q7Z1V1 |
Total number of polymer chains | 1 |
Total formula weight | 53536.80 |
Authors | Friggeri, L.,Wawrzak, Z.,Tortorella, S.,Lepesheva, G.I. (deposition date: 2013-12-31, release date: 2014-07-30, Last modification date: 2023-12-20) |
Primary citation | Friggeri, L.,Hargrove, T.Y.,Rachakonda, G.,Williams, A.D.,Wawrzak, Z.,Di Santo, R.,De Vita, D.,Waterman, M.R.,Tortorella, S.,Villalta, F.,Lepesheva, G.I. Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma Cruzi Sterol 14Alpha-Demethylase: Two Regions of the Enzyme Molecule Potentiate its Inhibition. J.Med.Chem., 57:6704-, 2014 Cited by PubMed: 25033013DOI: 10.1021/JM500739F PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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