4CIK

plasminogen kringle 1 in complex with inhibitor

Summary for 4CIK

Entry DOI	10.2210/pdb4cik/pdb
Descriptor	PLASMINOGEN, 5-[(2R,4S)-2-(phenylmethyl)piperidin-4-yl]-1,2-oxazol-3-one (3 entities in total)
Functional Keywords	hydrolase, fibrinolysis, plasminogen, protein-protein interaction, kringle ligand
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Secreted: P00747
Total number of polymer chains	1
Total formula weight	9837.87
Authors	Xue, Y.,Johansson, C.,Cheng, L.,Pettersen, D.,Gustafsson, D. (deposition date: 2013-12-10, release date: 2014-06-18, Last modification date: 2023-12-20)
Primary citation	Cheng, L.,Pettersen, D.,Ohlsson, B.,Schell, P.,Karle, M.,Evertsson, E.,Pahlen, S.,Jonforsen, M.,Plowright, A.T.,Bostrom, J.,Fex, T.,Thelin, A.,Hilgendorf, C.,Xue, Y.,Wahlund, G.,Lindberg, W.,Larsson, L.,Gustafsson, D. Discovery of the Fibrinolysis Inhibitor Azd6564, Acting Via Interference of a Protein-Protein Interaction. Acs Med.Chem.Lett., 5:538-, 2014 Cited by PubMed: 24900876 DOI: 10.1021/ML400526D PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation