4CGL

Leishmania major N-myristoyltransferase in complex with an aminoacylpyrrolidine inhibitor

Summary for 4CGL

Entry DOI	10.2210/pdb4cgl/pdb
Related	4CGM 4CGN 4CGO 4CGP
Descriptor	GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, (3R)-3-azanyl-4-(4-chlorophenyl)-1-[(3S,4R)-3-(4-chlorophenyl)-4-(hydroxymethyl)pyrrolidin-1-yl]butan-1-one, ... (5 entities in total)
Functional Keywords	transferase, myristoylation, inhibitor, aminoacylpyrrolidine
Biological source	LEISHMANIA MAJOR
Total number of polymer chains	1
Total formula weight	48919.66
Authors	Brannigan, J.A.,Roberts, S.M.,Bell, A.S.,Hutton, J.A.,Smith, D.F.,Tate, E.W.,Leatherbarrow, R.J.,Wilkinson, A.J. (deposition date: 2013-11-25, release date: 2014-07-09, Last modification date: 2014-11-05)
Primary citation	Brannigan, J.A.,Roberts, S.M.,Bell, A.S.,Hutton, J.A.,Hodgkinson, M.R.,Tate, E.W.,Leatherbarrow, R.J.,Smith, D.F.,Wilkinson, A.J. Diverse Modes of Binding in Structures of Leishmania Major N-Myristoyltransferase with Selective Inhibitors Iucrj, 1:250-, 2014 Cited by PubMed: 25075346 DOI: 10.1107/S2052252514013001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.48 Å)

Structure validation