4CG6

Cryo-em of the Sec61-complex bound to the 80s ribosome translating a membrane-inserting substrate

Summary for 4CG6

Entry DOI	10.2210/pdb4cg6/pdb
Related	4CG5 4CG7
EMDB information	2512
Descriptor	PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 1, PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT GAMMA, PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT BETA, ... (4 entities in total)
Functional Keywords	protein transport, co-translational protein translocation
Biological source	CANIS LUPUS FAMILIARIS (DOG) More
Cellular location	Endoplasmic reticulum membrane ; Multi-pass membrane protein : P38377 Endoplasmic reticulum membrane; Single-pass membrane protein: P60058 P60467
Total number of polymer chains	4
Total formula weight	71858.43
Authors	Gogala, M.,Becker, T.,Beatrix, B.,Barrio-Garcia, C.,Berninghausen, O.,Beckmann, R. (deposition date: 2013-11-21, release date: 2014-02-05, Last modification date: 2017-08-30)
Primary citation	Gogala, M.,Becker, T.,Beatrix, B.,Armache, J.,Barrio-Garcia, C.,Berninghausen, O.,Beckmann, R. Structures of the Sec61 Complex Engaged in Nascent Peptide Translocation or Membrane Insertion. Nature, 506:107-, 2014 Cited by PubMed: 24499919 DOI: 10.1038/NATURE12950 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (7.8 Å)

Structure validation