4CG6

Cryo-em of the Sec61-complex bound to the 80s ribosome translating a membrane-inserting substrate

Summary for 4CG6

Related4CG5 4CG7
EMDB information2512
DescriptorPROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 1, PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT GAMMA, PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT BETA, ... (4 entities in total)
Functional Keywordsprotein transport, co-translational protein translocation
Biological sourceCANIS LUPUS FAMILIARIS (DOG)
Cellular locationEndoplasmic reticulum membrane ; Multi-pass membrane protein  P38377
Endoplasmic reticulum membrane; Single-pass membrane protein P60058 P60467
Total number of polymer chains4
Total molecular weight71858.43
Authors
Gogala, M.,Becker, T.,Beatrix, B.,Barrio-Garcia, C.,Berninghausen, O.,Beckmann, R. (deposition date: 2013-11-21, release date: 2014-02-05, Last modification date: 2017-08-30)
Primary citation
Gogala, M.,Becker, T.,Beatrix, B.,Armache, J.,Barrio-Garcia, C.,Berninghausen, O.,Beckmann, R.
Structures of the Sec61 Complex Engaged in Nascent Peptide Translocation or Membrane Insertion.
Nature, 506:107-, 2014
PubMed: 24499919 (PDB entries with the same primary citation)
DOI: 10.1038/NATURE12950
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY (7.8 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers212.0%8.0%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 4cg6
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Molmil generated image of 4cg6
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Molmil generated image of 4cg6
rotated about y axis by 90°