4CET

Crystal structure of the complex of the P187S variant of human NAD(P) H:quinone oxidoreductase with dicoumarol at 2.2 A resolution

4CET の概要

• エントリーDOI: 10.2210/pdb4cet/pdb
• 分子名称: NAD(P)H DEHYDROGENASE [QUINONE] 1, FLAVIN-ADENINE DINUCLEOTIDE, BISHYDROXY[2H-1-BENZOPYRAN-2-ONE,1,2-BENZOPYRONE], ... (4 entities in total)
• 機能のキーワード: coumarin-based inhibitors, nq01, fad, flavoprotein, nad, nadp, nadph, oxidoreductase, oxidoreductase-inhibitor complex, single amino acid exchange, p187s
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm: P15559
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34190.78

構造登録者

Lienhart, W.D.,Gudipati, V.,Uhl, M.K.,Binter, A.,Pulido, S.,Saf, R.,Zangger, K.,Gruber, K.,Macheroux, P. (登録日: 2013-11-12, 公開日: 2014-08-27, 最終更新日: 2023-12-20)

主引用文献

Lienhart, W.-D.,Gudipati, V.,Uhl, M.K.,Binter, A.,Pulido, S.,Saf, R.,Zangger, K.,Gruber, K.,Macheroux, P.
Collapse of the Native Structure by a Single Amino Acid Exchange in Human Nad(P)H:Quinone Oxidoreductase (Nqo1).
FEBS J., 281:4691-, 2014

PubMed Abstract: Human

PubMed: 25143260
DOI: 10.1111/FEBS.12975

実験手法

X-RAY DIFFRACTION (2.2 Å)