4CDF

Human DPP1 in complex with (2S,4S)-N-((1S)-1-cyano-2-(4-(4- cyanophenyl)phenyl)ethyl)-4-hydroxy-piperidine-2-carboxamide

Summary for 4CDF

Entry DOI	10.2210/pdb4cdf/pdb
Related	4CDC 4CDD 4CDE
Descriptor	DIPEPTIDYL PEPTIDASE 1 EXCLUSION DOMAIN CHAIN, DIPEPTIDYL PEPTIDASE 1 HEAVY CHAIN, DIPEPTIDYL PEPTIDASE 1 LIGHT CHAIN, ... (7 entities in total)
Functional Keywords	hydrolase, inhibitor
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	6
Total formula weight	81564.41
Authors	Debreczeni, J.,Edman, K.,Furber, M.,Tiden, A.,Gardiner, P.,Mete, T.,Ford, R.,Millichip, I.,Stein, L.,Mather, A.,Kinchin, E.,Luckhurst, C.,Cage, P.,Sanghanee, H.,Breed, J.,Wissler, L. (deposition date: 2013-10-31, release date: 2014-03-19, Last modification date: 2023-12-20)
Primary citation	Furber, M.,Gardiner, P.,Tiden, A.K.,Mete, A.,Ford, R.,Millichip, I.,Stein, L.,Mather, A.,Kinchin, E.,Luckhurst, C.,Barber, S.,Cage, P.,Sanganee, H.,Austin, R.,Chohan, K.,Beri, R.,Thong, B.,Wallace, A.,Oreffo, V.,Hutchinson, R.,Harper, S.,Debreczeni, J.,Breed, J.,Wissler, L.,Edman, K. Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate. J.Med.Chem., 57:2357-, 2014 Cited by PubMed: 24592859 DOI: 10.1021/JM401705G PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation