4CDC

Human DPP1 in complex with (2S)-2-amino-N-((1S)-1-cyano-2-(4- phenylphenyl)ethyl)butanamide

4CDC の概要

• エントリーDOI: 10.2210/pdb4cdc/pdb
• 関連するPDBエントリー: 4CDD 4CDE 4CDF
• 分子名称: DIPEPTIDYL PEPTIDASE 1 EXCLUSION DOMAIN CHAIN, DIPEPTIDYL PEPTIDASE 1 HEAVY CHAIN, DIPEPTIDYL PEPTIDASE 1 LIGHT CHAIN, ... (8 entities in total)
• 機能のキーワード: hydrolase, inhibitor
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 162150.76

構造登録者

Debreczeni, J.,Edman, K.,Furber, M.,Tiden, A.,Gardiner, P.,Mete, T.,Ford, R.,Millichip, I.,Stein, L.,Mather, A.,Kinchin, E.,Luckhurst, C.,Cage, P.,Sanghanee, H.,Breed, J.,Wissler, L. (登録日: 2013-10-31, 公開日: 2014-03-19, 最終更新日: 2024-10-16)

主引用文献

Furber, M.,Gardiner, P.,Tiden, A.K.,Mete, A.,Ford, R.,Millichip, I.,Stein, L.,Mather, A.,Kinchin, E.,Luckhurst, C.,Barber, S.,Cage, P.,Sanganee, H.,Austin, R.,Chohan, K.,Beri, R.,Thong, B.,Wallace, A.,Oreffo, V.,Hutchinson, R.,Harper, S.,Debreczeni, J.,Breed, J.,Wissler, L.,Edman, K.
Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate.
J.Med.Chem., 57:2357-, 2014

PubMed Abstract: A lead generation and optimization program delivered the highly selective and potent CatC inhibitor 10 as an in vivo tool compound and potential development candidate. Structural studies were undertaken to generate SAR understanding.

PubMed: 24592859
DOI: 10.1021/JM401705G

実験手法

X-RAY DIFFRACTION (2.4 Å)