4CCV

Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an interdomain disulfide bridge: Implications for the regulation of angiogenesis

Summary for 4CCV

Entry DOI	10.2210/pdb4ccv/pdb
Descriptor	HISTIDINE-RICH GLYCOPROTEIN, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTATHIONE, ... (5 entities in total)
Functional Keywords	blood clotting, coagulation, cystatin, s-glutathionylation
Biological source	ORYCTOLAGUS CUNICULUS (RABBIT)
Total number of polymer chains	1
Total formula weight	14513.82
Authors	McMahon, S.A.,Kassaar, O.,Stewart, A.J.,Naismith, J.H. (deposition date: 2013-10-29, release date: 2014-02-19, Last modification date: 2020-07-29)
Primary citation	Kassaar, O.,Mcmahon, S.A.,Thompson, R.,Botting, C.H.,Naismith, J.H.,Stewart, A.J. Crystal Structure of Histidine-Rich Glycoprotein N2 Domain Reveals Redox Activity at an Interdomain Disulfide Bridge: Implications for Angiogenic Regulation. Blood, 123:1948-, 2014 Cited by PubMed: 24501222 DOI: 10.1182/BLOOD-2013-11-535963 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.93 Å)

Structure validation