4CAO

Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-(2-(3-(3-Fluorophenyl(propylamino)ethyl))quinolin-2- amine

Summary for 4CAO

Entry DOI	10.2210/pdb4cao/pdb
Related	4CAM 4CAN 4CAP 4CAQ 4CAR 4CDT 4CFT
Descriptor	NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywords	oxidoreductase, nitric oxide synthase, inhibitor complex
Biological source	RATTUS NORVEGICUS (NORWAY RAT)
Cellular location	Cell membrane, sarcolemma; Peripheral membrane protein (By similarity): P29476
Total number of polymer chains	2
Total formula weight	100170.83
Authors	Li, H.,Poulos, T.L. (deposition date: 2013-10-08, release date: 2014-02-19, Last modification date: 2014-03-12)
Primary citation	Cinelli, M.A.,Li, H.,Chreifi, G.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Simplified 2-Aminoquinoline-Based Scaffold for Potent and Selective Neuronal Nitric Oxide Synthase Inhibition. J.Med.Chem., 57:1513-, 2014 Cited by PubMed: 24472039 DOI: 10.1021/JM401838X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation