4CAO

Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-(2-(3-(3-Fluorophenyl(propylamino)ethyl))quinolin-2- amine

4CAO の概要

• エントリーDOI: 10.2210/pdb4cao/pdb
• 関連するPDBエントリー: 4CAM 4CAN 4CAP 4CAQ 4CAR 4CDT 4CFT
• 分子名称: NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: oxidoreductase, nitric oxide synthase, inhibitor complex
• 由来する生物種: RATTUS NORVEGICUS (NORWAY RAT)
• 細胞内の位置: Cell membrane, sarcolemma; Peripheral membrane protein (By similarity): P29476
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100170.83

構造登録者

Li, H.,Poulos, T.L. (登録日: 2013-10-08, 公開日: 2014-02-19, 最終更新日: 2014-03-12)

• 主引用文献: Cinelli, M.A.,Li, H.,Chreifi, G.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.; Simplified 2-Aminoquinoline-Based Scaffold for Potent and Selective Neuronal Nitric Oxide Synthase Inhibition.; J.Med.Chem., 57:1513-, 2014; PubMed: 24472039; DOI: 10.1021/JM401838X

実験手法

X-RAY DIFFRACTION (1.98 Å)