4C8R

Human gamma-butyrobetaine dioxygenase (BBOX1) in complex with Ni(II) and N-(3-hydroxypicolinoyl)-S-(pyridin-2-ylmethyl)-L-cysteine (AR692B)

Summary for 4C8R

Entry DOI	10.2210/pdb4c8r/pdb
Descriptor	GAMMA-BUTYROBETAINE DIOXYGENASE, NICKEL (II) ION, ZINC ION, ... (6 entities in total)
Functional Keywords	oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase 1, dsbh, facial triad, gamma-butyrobetaine, hydroxylase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	6
Total formula weight	272785.41
Authors	Chowdhury, R.,Rydzik, A.M.,Kochan, G.T.,McDonough, M.A.,Schofield, C.J. (deposition date: 2013-10-01, release date: 2014-05-14, Last modification date: 2023-12-20)
Primary citation	Rydzik, A.M.,Chowdhury, R.,Kochan, G.T.,Williams, S.T.,McDonough, M.A.,Kawamura, A.,Schofield, C.J. Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of gamma-butyrobetaine hydroxylase. Chem Sci, 5:1765-1771, 2014 Cited by PubMed: 26682037 DOI: 10.1039/C4SC00020J PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.82 Å)

Structure validation