4C8R

Human gamma-butyrobetaine dioxygenase (BBOX1) in complex with Ni(II) and N-(3-hydroxypicolinoyl)-S-(pyridin-2-ylmethyl)-L-cysteine (AR692B)

4C8R の概要

• エントリーDOI: 10.2210/pdb4c8r/pdb
• 分子名称: GAMMA-BUTYROBETAINE DIOXYGENASE, NICKEL (II) ION, ZINC ION, ... (6 entities in total)
• 機能のキーワード: oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase 1, dsbh, facial triad, gamma-butyrobetaine, hydroxylase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 272785.41

構造登録者

Chowdhury, R.,Rydzik, A.M.,Kochan, G.T.,McDonough, M.A.,Schofield, C.J. (登録日: 2013-10-01, 公開日: 2014-05-14, 最終更新日: 2023-12-20)

• 主引用文献: Rydzik, A.M.,Chowdhury, R.,Kochan, G.T.,Williams, S.T.,McDonough, M.A.,Kawamura, A.,Schofield, C.J.; Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of gamma-butyrobetaine hydroxylase.; Chem Sci, 5:1765-1771, 2014; PubMed: 26682037; DOI: 10.1039/C4SC00020J

実験手法

X-RAY DIFFRACTION (2.82 Å)