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4C81

IspF (Plasmodium falciparum) CDP complex

Summary for 4C81
Entry DOI10.2210/pdb4c81/pdb
Related4C82 4C8E 4C8G 4C8I
Descriptor2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE, ZINC ION, CYTIDINE-5'-DIPHOSPHATE, ... (6 entities in total)
Functional Keywordslyase
Biological sourcePLASMODIUM FALCIPARUM
Total number of polymer chains1
Total formula weight21311.00
Authors
O'Rourke, P.E.F.,Kalinowska-Tluscik, J.,Fyfe, P.K.,Dawson, A.,Hunter, W.N. (deposition date: 2013-09-27, release date: 2014-01-08, Last modification date: 2023-12-20)
Primary citationO Rourke, P.E.,Kalinowska-Tluscik, J.,Fyfe, P.K.,Dawson, A.,Hunter, W.N.
Crystal Structures of Ispf from Plasmodium Falciparum and Burkholderia Cenocepacia: Comparisons Inform Antimicrobial Drug Target Assessment.
Bmc Struct.Biol., 14:1-, 2014
Cited by
PubMed Abstract: 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase (IspF) catalyzes the conversion of 4-diphosphocytidyl-2C-methyl-D-erythritol-2-phosphate to 2C-methyl-D-erythritol-2,4-cyclodiphosphate and cytidine monophosphate in production of isoprenoid-precursors via the methylerythritol phosphate biosynthetic pathway. IspF is found in the protozoan Plasmodium falciparum, a parasite that causes cerebral malaria, as well as in many Gram-negative bacteria such as Burkholderia cenocepacia. IspF represents a potential target for development of broad-spectrum antimicrobial drugs since it is proven or inferred as essential in these pathogens and absent from mammals. Structural studies of IspF from these two important yet distinct pathogens, and comparisons with orthologues have been carried out to generate reagents, to support and inform a structure-based approach to early stage drug discovery.
PubMed: 24410837
DOI: 10.1186/1472-6807-14-1
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.56 Å)
Structure validation

226707

数据于2024-10-30公开中

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