4C7T

Focal Adhesion Kinase catalytic domain in complex with a diarylamino- 1,3,5-triazine inhibitor

4C7T の概要

• エントリーDOI: 10.2210/pdb4c7t/pdb
• 分子名称: FOCAL ADHESION KINASE 1, N-methyl-2-[[4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl]amino]benzamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: transferase, kinase inhibitor, atp-binding, integrin signaling
• 由来する生物種: GALLUS GALLUS (CHICKEN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32238.29

構造登録者

Le Coq, J.,Lietha, D. (登録日: 2013-09-25, 公開日: 2014-04-02, 最終更新日: 2023-12-20)

• 主引用文献: Dao, P.,Jarray, R.,Smith, N.,Lepelletier, Y.,Le Coq, J.,Lietha, D.,Hadj-Slimane, R.,Herbeuval, J.P.,Garbay, C.,Raynaud, F.,Chen, H.; Inhibition of Both Focal Adhesion Kinase and Fibroblast Growth Factor Receptor 2 Pathways Induces Anti-Tumor and Anti-Angiogenic Activities.; Cancer Lett., 348:88-, 2014; PubMed: 24657306; DOI: 10.1016/J.CANLET.2014.03.007

実験手法

X-RAY DIFFRACTION (2.05 Å)