4C6L

Crystal structure of the dihydroorotase domain of human CAD bound to the inhibitor fluoroorotate at pH 6.0

Summary for 4C6L

Related4C6B 4C6C 4C6D 4C6E 4C6F 4C6I 4C6J 4C6K 4C6M 4C6N 4C6O 4C6P 4C6Q
DescriptorCAD PROTEIN, ZINC ION, FORMIC ACID, ... (5 entities in total)
Functional Keywordshydrolase, de novo pyrimidine biosynthesis, amidohydrolase superfamily, metalloenzyme, zinc binding, histidinate anion
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm P27708
Total number of polymer chains1
Total molecular weight43312.98
Authors
Ramon-Maiques, S.,Lallous, N.,Grande-Garcia, A. (deposition date: 2013-09-18, release date: 2014-02-05, Last modification date: 2014-02-19)
Primary citation
Grande-Garcia, A.,Lallous, N.,Diaz-Tejada, C.,Ramon-Maiques, S.
Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad.
Structure, 22:185-, 2014
PubMed: 24332717 (PDB entries with the same primary citation)
DOI: 10.1016/J.STR.2013.10.016
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.55 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.15520.6%0.7%1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4c6l
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Molmil generated image of 4c6l
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Molmil generated image of 4c6l
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More Biological unit images

Molmil generated image of 4c6l
no rotation
Molmil generated image of 4c6l
rotated about x axis by 90°
Molmil generated image of 4c6l
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4c6l.pdb1.gz [382.63 KB])