4C4N

Crystal structure of the Sonic Hedgehog-heparin complex

4C4N の概要

• エントリーDOI: 10.2210/pdb4c4n/pdb
• 関連するPDBエントリー: 4C4M
• 分子名称: SONIC HEDGEHOG PROTEIN, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: signaling protein, hedgehog signalling, morphogens, heparan sulphate proteoglycans, glycosaminoglycans
• 由来する生物種: MUS MUSCULUS (HOUSE MOUSE)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 41363.47

構造登録者

Whalen, D.M.,Malinauskas, T.,Gilbert, R.J.C.,Siebold, C. (登録日: 2013-09-05, 公開日: 2013-10-02, 最終更新日: 2024-05-08)

• 主引用文献: Whalen, D.M.,Malinauskas, T.,Gilbert, R.J.C.,Siebold, C.; Structural Insights Into Proteoglycan-Shaped Hedgehog Signaling.; Proc.Natl.Acad.Sci.USA, 110:16420-, 2013; PubMed: 24062467; DOI: 10.1073/PNAS.1310097110

実験手法

X-RAY DIFFRACTION (2.36 Å)