4C1I

Selective Inhibitors of PDE2, PDE9, and PDE10: Modulators of Activity of the Central Nervous System

4C1I の概要

• エントリーDOI: 10.2210/pdb4c1i/pdb
• 分子名称: CGMP-DEPENDENT 3', 5'-CYCLIC PHOSPHODIESTERASE, (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol, ZINC ION, ... (5 entities in total)
• 機能のキーワード: hydrolase, hydrolase inhibitor complex
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Isoform PDE2A3: Cell membrane; Lipid-anchor. Isoform PDE2A2: Mitochondrion matrix. Isoform PDE2A1: Cytoplasm. Isoform 5: Mitochondrion (Probable): O00408
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 167197.82

構造登録者

Jorgensen, M.,Kehler, J.,Langgard, M.,Svenstrup, N.,Tagmose, L. (登録日: 2013-08-12, 公開日: 2014-08-27, 最終更新日: 2023-12-20)

• 主引用文献: Jorgensen, M.,Kehler, J.,Langgard, M.,Svenstrup, N.,Tagmose, L.; Chapter 4: Selective Inhibitors of Pde2, Pde9, and Pde10: Modulators of Activity of the Central Nervous System; To be Published,

実験手法

X-RAY DIFFRACTION (2.4 Å)