4BZO

Crystal structure of PIM1 in complex with a Pyrrolo-Pyrazinone inhibitor

Summary for 4BZO

• Entry DOI: 10.2210/pdb4bzo/pdb
• Related: 4BZN
• Descriptor: SERINE/THREONINE-PROTEIN KINASE PIM-1, N-[(1S)-2-AMINO-1-PHENYLETHYL]-2-[(4S)-7-(2-FLUORO-4-PYRIDINYL)-1-OXO-1,2,3,4-TETRAHYDROPYRROLO[1,2-A]PYRAZIN-4-YL]ACETAMIDE (3 entities in total)
• Functional Keywords: pim1, atp binding, kinase inhibitor, transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• Total number of polymer chains: 1
• Total formula weight: 36243.13

Authors

Casale, E.,Casuscelli, F.,Ardini, E.,Avanzi, N.,Cervi, G.,D'Anello, M.,Donati, D.,Faiardi, D.,Ferguson, R.D.,Fogliatto, G.,Galvani, A.,Marsiglio, A.,Mirizzi, D.G.,Montemartini, M.,Orrenius, C.,Papeo, G.,Piutti, C.,Salom, B.,Felder, E.R. (deposition date: 2013-07-29, release date: 2013-10-30, Last modification date: 2013-11-13)

• Primary citation: Casuscelli, F.,Ardini, E.,Avanzi, N.,Casale, E.,Cervi, G.,D'Anello, M.,Donati, D.,Faiardi, D.,Ferguson, R.D.,Fogliatto, G.,Galvani, A.,Marsiglio, A.,Mirizzi, D.G.,Montemartini, M.,Orrenius, C.,Papeo, G.,Piutti, C.,Salom, B.,Felder, E.R.; Discovery and Optimization of Pyrrolo[1,2-A]Pyrazinones Leads to Novel and Selective Inhibitors of Pim Kinases.; Bioorg.Med.Chem., 21:7364-, 2013; PubMed: 24139169; DOI: 10.1016/J.BMC.2013.09.054

Experimental method

X-RAY DIFFRACTION (2.1 Å)