4BZN

Crystal structure of PIM1 in complex with a Pyrrolo(1,2-a)Pyrazinone inhibitor

Summary for 4BZN

Entry DOI	10.2210/pdb4bzn/pdb
Related	4BZO
Descriptor	SERINE/THREONINE-PROTEIN KINASE PIM-1, N-(2,2-dimethylpropyl)-2-[1-oxo-7-(thiophen-3-yl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetamide (3 entities in total)
Functional Keywords	pim1, atp binding, kinase inhibitor, transferase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	36181.15
Authors	Casale, E.,Casuscelli, F.,Ardini, E.,Avanzi, N.,Cervi, G.,D'Anello, M.,Donati, D.,Faiardi, D.,Ferguson, R.D.,Fogliatto, G.,Galvani, A.,Marsiglio, A.,Mirizzi, D.G.,Montemartini, M.,Orrenius, C.,Papeo, G.,Piutti, C.,Salom, B.,Felder, E.R. (deposition date: 2013-07-29, release date: 2013-10-30, Last modification date: 2023-12-20)
Primary citation	Casuscelli, F.,Ardini, E.,Avanzi, N.,Casale, E.,Cervi, G.,D'Anello, M.,Donati, D.,Faiardi, D.,Ferguson, R.D.,Fogliatto, G.,Galvani, A.,Marsiglio, A.,Mirizzi, D.G.,Montemartini, M.,Orrenius, C.,Papeo, G.,Piutti, C.,Salom, B.,Felder, E.R. Discovery and Optimization of Pyrrolo[1,2-A]Pyrazinones Leads to Novel and Selective Inhibitors of Pim Kinases. Bioorg.Med.Chem., 21:7364-, 2013 Cited by PubMed: 24139169 DOI: 10.1016/J.BMC.2013.09.054 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation