4BXK

Crystal structure of the Angiotensin-1 converting enzyme N-domain in complex with a domain-specific inhibitor

Summary for 4BXK

Entry DOI	10.2210/pdb4bxk/pdb
Descriptor	ANGIOTENSIN-CONVERTING ENZYME, CHLORIDE ION, TETRAETHYLENE GLYCOL, ... (13 entities in total)
Functional Keywords	hydrolase, metalloprotease, protease inhibitor
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	150421.73
Authors	Douglas, R.G.,Sharma, R.K.,Masuyer, G.,Lubbe, L.,Zamora, I.,Acharya, K.R.,Chibale, K.,Sturrock, E.D. (deposition date: 2013-07-12, release date: 2013-09-18, Last modification date: 2023-12-20)
Primary citation	Douglas, R.G.,Sharma, R.K.,Masuyer, G.,Lubbe, L.,Zamora, I.,Acharya, K.R.,Chibale, K.,Sturrock, E.D. Fragment-Based Design for the Development of N-Domain Selective Angiotensin-1 Converting Enzyme Inhibitors Clin.Sci., 126:305-, 2014 Cited by PubMed: 24015848 DOI: 10.1042/CS20130403 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation