4BWR

Crystal structure of c5321: a protective antigen present in uropathogenic Escherichia coli strains displaying an SLR fold

「2XM6」から置き換えられました

4BWR の概要

• エントリーDOI: 10.2210/pdb4bwr/pdb
• 分子名称: PROTEIN CORRESPONDING TO LOCUS C5321 FROM CFT073 E.COLI STRAIN, MAGNESIUM ION, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: unknown function, sel1-like repeat, super-helical fold
• 由来する生物種: ESCHERICHIA COLI
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 54902.52

構造登録者

Urosev, D.,Ferrer-Navarro, M.,Pastorello, I.,Cartocci, E.,Costenaro, L.,Zhulenkovs, D.,Marechal, J.-D.,Leonchiks, A.,Reverter, D.,Serino, L.,Soriani, M.,Daura, X. (登録日: 2013-07-04, 公開日: 2013-07-24, 最終更新日: 2024-11-20)

主引用文献

Urosev, D.,Ferrer-Navarro, M.,Pastorello, I.,Cartocci, E.,Costenaro, L.,Zhulenkovs, D.,Marechal, J.,Leonchiks, A.,Reverter, D.,Serino, L.,Soriani, M.,Daura, X.
Crystal Structure of C5321: A Protective Antigen Present in Uropathogenic Escherichia Coli Strains Displaying an Slr Fold.
Bmc Struct.Biol., 13:19-, 2013

PubMed Abstract: Increasing rates of antimicrobial resistance among uropathogens led, among other efforts, to the application of subtractive reverse vaccinology for the identification of antigens present in extraintestinal pathogenic E. coli (ExPEC) strains but absent or variable in non-pathogenic strains, in a quest for a broadly protective Escherichia coli vaccine. The protein coded by locus c5321 from CFT073 E. coli was identified as one of nine potential vaccine candidates against ExPEC and was able to confer protection with an efficacy of 33% in a mouse model of sepsis. c5321 (known also as EsiB) lacks functional annotation and structurally belongs to the Sel1-like repeat (SLR) family. Herein, as part of the general characterization of this potential antigen, we have focused on its structural properties.

PubMed: 24099525
DOI: 10.1186/1472-6807-13-19

実験手法

X-RAY DIFFRACTION (1.74 Å)