4BUH

Human IgE against the major allergen Bet v 1 - Crystal structure of clone M0418 scFv

4BUH の概要

• エントリーDOI: 10.2210/pdb4buh/pdb
• 分子名称: CLONE M0418 SCFV, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
• 機能のキーワード: immune system, antibody, allergen
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57785.20

構造登録者

Davies, A.M.,Levin, M.,Lilljekvist, M.,Carlsson, F.,Gould, H.J.,Sutton, B.J.,Ohlin, M. (登録日: 2013-06-20, 公開日: 2013-11-20, 最終更新日: 2024-11-20)

主引用文献

Levin, M.,Davies, A.M.,Lilljekvist, M.,Carlsson, F.,Gould, H.J.,Sutton, B.J.,Ohlin, M.
Human Ige Against the Major Allergen Bet V 1 - Defining an Epitope with Limited Cross-Reactivity between Different Pr-10 Family Proteins
Clin.Exp.Allergy, 44:288-, 2014

PubMed Abstract: The interaction between IgE and allergen is a key event at the initiation of an allergic response, and its characteristics have substantial effects on the clinical manifestation. Despite this, the molecular details of the interaction between human IgE and the major birch allergen Bet v 1, one of the most potent tree allergens, still remain poorly investigated.

PubMed: 24447087
DOI: 10.1111/CEA.12230

実験手法

X-RAY DIFFRACTION (1.3 Å)