4BTY

Crystal structure of human vascular adhesion protein-1 in complex with pyridazinone inhibitors

4BTY の概要

• エントリーDOI: 10.2210/pdb4bty/pdb
• 関連するPDBエントリー: 4BTW 4BTX
• 分子名称: MEMBRANE PRIMARY AMINE OXIDASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Membrane; Single-pass type II membrane protein: Q16853
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 168093.85

構造登録者

Bligt-Linden, E.,Pihlavisto, M.,Szatmari, I.,Otwinowski, Z.,Smith, D.J.,Lazar, L.,Fulop, F.,Salminen, T.A. (登録日: 2013-06-19, 公開日: 2013-12-18, 最終更新日: 2023-12-20)

• 主引用文献: Bligt-Linden, E.,Pihlavisto, M.,Szatmari, I.,Otwinowski, Z.,Smith, D.J.,Lazar, L.,Fulop, F.,Salminen, T.A.; Novel Pyridazinone Inhibitors for Vascular Adhesion Protein- 1 (Vap-1): Old Target - New Inhibition Mode.; J.Med.Chem., 56:9837-, 2013; PubMed: 24304424; DOI: 10.1021/JM401372D

実験手法

X-RAY DIFFRACTION (3.1 Å)