4BQP

Mtb InhA complex with Methyl-thiazole compound 7

4BQP の概要

• エントリーDOI: 10.2210/pdb4bqp/pdb
• 関連するPDBエントリー: 4BQR
• 分子名称: ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, acp enoyl reductase
• 由来する生物種: MYCOBACTERIUM TUBERCULOSIS
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 177939.14

構造登録者

Read, J.A.,Gingell, H.,Madhavapeddi, P.,Shirude, P.S. (登録日: 2013-05-31, 公開日: 2013-12-11, 最終更新日: 2024-05-08)

• 主引用文献: Shirude, P.S.,Madhavapeddi, P.,Naik, M.,Murugan, K.,Shinde, V.,Nandishaiah, R.,Bhat, J.,Kumar, A.,Hameed, S.,Holdgate, G.,Davies, G.,Mcmiken, H.,Hegde, N.,Ambady, A.,Venkatraman, J.,Panda, M.,Bandodkar, B.,Sambandamurthy, V.K.,Read, J.A.; Methyl-Thiazoles: A Novel Mode of Inhibition with the Potential to Develop Novel Inhibitors Targeting Inha in Mycobacterium Tuberculosis.; J.Med.Chem., 56:8533-, 2013; PubMed: 24107081; DOI: 10.1021/JM4012033

実験手法

X-RAY DIFFRACTION (1.89 Å)